DataElement
publicId 8120269
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longName Biospecimen Stain Type
shortName 8119796v1.0:8119914v1.0
definition The name of the dye or other coloring material used in microscopy to make biological sample structures visible.
context MCL
origin MCL:Molecular and Cellular Characterization of Screened Lesions
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2022-03-25
endDate
changeDescription 4/28/22 mr Released per SME. 3/25/22 mr Created for MCL path imaging per DCT.
administrativeNotes 5/22/25 Classified in GDC Candidate CSI, added alt name, alt def, per June 2025 GDC DD. sl; 1/2/25 Added PV Wright-Giemsa for IDC via Pat Dunn email 12/30/24. mr; 10/29/24 per Henry/CodeMap task, add alt table LS;
unresolvedIssues
deletedIndicator No
createdBy COLBERTM
dateCreated 2022-03-25
modifiedBy SLAUER
dateModified 2025-05-22
DataElementConcept
publicId 8119796
version 1
longName Biospecimen Stain
shortName 2859635v1.0:2619589v1.0
definition Any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products._A dye or other coloring material that is used in microscopy to make structures visible.
context MCL
origin MCL:Molecular and Cellular Characterization of Screened Lesions
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2022-03-24
endDate
changeDescription 4/28/22 mr Released per SME. 3/24/22 mr Created for MCL path imaging per DCT.
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy COLBERTM
dateCreated 2022-03-24
modifiedBy COLBERTM
dateModified 2022-04-28
ObjectClass
publicId 2859635
version 1
longName Biospecimen
shortName C70699
definition Any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products.
context NCIP
origin NCI Thesaurus
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2009-04-01
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy UMLLOADER_TAVERNA
dateCreated 2009-04-01
modifiedBy ONEDATA
dateModified 2009-04-01
Concepts
longName Biospecimen
conceptCode C70699
definition Any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
Property
publicId 2619589
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longName Stain
shortName C841
definition A dye or other coloring material that is used in microscopy to make structures visible.
context NCIP
origin NCI Thesaurus
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2007-03-28
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy UMLLOADER_CAELMIR
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modifiedBy SBREXT
dateModified 2007-11-07
Concepts
longName Stain
conceptCode C841
definition A dye or other coloring material that is used in microscopy to make structures visible.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
ConceptualDomain
publicId 2435018
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longName Clinical or Research Activity
shortName C16203
definition Any specific activity undertaken during the course of a clinical study or research protocol.
context NCIP
origin NCI Thesaurus
workflowStatus RELEASED
registrationStatus Application
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endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy CURTIST
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ValueDomain
publicId 8119914
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longName Stain Type
shortName 8119914v1.0
definition A dye or other coloring material that is used in microscopy to make structures visible._Something distinguishable as an identifiable class based on common qualities.
context MCL
type Enumerated
dataType CHARACTER
minLength
maxLength 30
minValue
maxValue
decimalPlace
origin MCL:Molecular and Cellular Characterization of Screened Lesions
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2022-03-25
endDate
changeDescription 4/28/22 mr Released per SME. 3/25/22 mr Created for MCL path imaging per DCT.
administrativeNotes 1/2/25 Added PV Wright-Giemsa for IDC via Pat Dunn email 12/30/24. mr;
unresolvedIssues
deletedIndicator No
createdBy COLBERTM
dateCreated 2022-03-25
modifiedBy TYRRELLM
dateModified 2026-08-25
PermissibleValues
publicId 9090860
value Other
valueDescription Other
origin
beginDate 2022-03-25
endDate
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ValueMeaning
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definition Different than the one(s) previously specified or mentioned.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2010-08-04
endDate
changeDescription Concept annotation added for UPitt/TCGA. Ylu, 02/03/2015.
administrativeNotes 2023.3.7 Alt VM added per ticket request CADSR0002119. ak
unresolvedIssues
deletedIndicator No
createdBy MAESKEB
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dateModified 2026-06-08
Concepts
longName Other
conceptCode C17649
definition Different than the one(s) previously specified or mentioned.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
Designations
languageName ENGLISH
name Other
type VM Alt Name
context COG
id C7D2DD99-CAFA-656F-E053-4EBD850A1AAE
createdBy Linda Springer
dateCreated 2021-07-23
modifiedBy ONEDATA
dateModified 2021-07-23
languageName ENGLISH
name Other, please specify
type VM Alt Name
context OCG
id 5A6B15D9-4F40-7DE0-E053-F662850AA028
createdBy Mary J Cooper
dateCreated 2017-09-30
modifiedBy ONEDATA
dateModified 2017-09-30
languageName ENGLISH
name Other (specify)
type HCMI Name
context OCG
id 5BC14564-6678-086F-E053-F662850A4588
createdBy Mary J Cooper
dateCreated 2017-10-17
modifiedBy ONEDATA
dateModified 2017-10-17
languageName ENGLISH
name Other
type VM Alt Name
context Theradex
id A900324F-65EA-6787-E053-4EBD850AA760
createdBy Tina Taylor
dateCreated 2020-06-26
modifiedBy ONEDATA
dateModified 2020-06-26
languageName ENGLISH
name Other, specify:
type VM Alt Name
context NCIP
id AB9692F8-8765-64C9-E053-4EBD850A545B
createdBy Angela Kummerow
dateCreated 2020-07-29
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name Other(s), please specify:
type VM Alt Name
context NCIP
id AB1D9AED-D418-5F27-E053-4EBD850A7BB9
createdBy Angela Kummerow
dateCreated 2020-07-23
modifiedBy ONEDATA
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name Other, Specify
type VM Alt Name
context CCR
id AB9591D8-23A3-5F1E-E053-4EBD850A8586
createdBy Angela Kummerow
dateCreated 2020-07-29
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languageName ENGLISH
name Other (specify here)
type VM Alt Name
context DCP
id B0A4A073-2DFA-05CF-E053-4EBD850ABF5B
createdBy Irina Titarenko
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languageName ENGLISH
name Other (i.e. leukapheresis)
type VM Alt Name
context COG
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createdBy Angela Kummerow
dateCreated 2023-03-07
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name OTHER (SPECIFY)
type VM Alt Name
context Theradex
id 53BF41B8-5CA9-2705-E063-731AD00AB677
createdBy Lamia Sokker
dateCreated 2026-06-08
modifiedBy SOKKERL
dateModified 2026-06-08
publicId 9090861
value H&E
valueDescription Hematoxylin and Eosin Staining Method
origin
beginDate 2022-03-25
endDate
deletedIndicator No
createdBy COLBERTM
dateCreated 2022-03-25
modifiedBy ONEDATA
dateModified 2022-03-25
ValueMeaning
publicId 4588572
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longName Hematoxylin and Eosin Staining Method
shortName 4588572
definition Hematoxylin-and-eosin, or H&E, is a routine staining procedure of tissue sections. This staining method uses two separate dyes, one staining the nucleus and the other staining the cytoplasm and connective tissue. Hematoxylin is a dark purplish dye that stains the chromatin (nuclear material) within the nucleus. Eosin is an orangish-pink to red dye that stains the cytoplasmic material including connective tissue and collagen.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2014-11-12
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy COOPERM
dateCreated 2014-11-12
modifiedBy COLBERTM
dateModified 2026-04-22
Concepts
longName Hematoxylin and Eosin Staining Method
conceptCode C23011
definition Hematoxylin-and-eosin, or H&E, is a routine staining procedure of tissue sections. This staining method uses two separate dyes, one staining the nucleus and the other staining the cytoplasm and connective tissue. Hematoxylin is a dark purplish dye that stains the chromatin (nuclear material) within the nucleus. Eosin is an orangish-pink to red dye that stains the cytoplasmic material including connective tissue and collagen.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
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languageName ENGLISH
name H&E
type VM Alt Name
context COG
id 1B531F1F-001C-2672-E050-BB89AD4323C2
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dateCreated 2015-07-20
modifiedBy ONEDATA
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name hande
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context CRDC
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createdBy Maureen Ryan
dateCreated 2026-04-22
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value mIHC
valueDescription Multiplexed Immunohistochemistry
origin
beginDate 2022-03-25
endDate
deletedIndicator No
createdBy COLBERTM
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modifiedBy ONEDATA
dateModified 2022-03-25
ValueMeaning
publicId 7789191
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longName Multiplexed Immunohistochemistry
shortName 7789191
definition A method that enables simultaneous detection of multiple biomarkers on a single tissue section using immunohistochemistry techniques.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
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changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy KNABLEJ
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dateModified 2021-09-28
Concepts
longName Multiplexed Immunohistochemistry
conceptCode C181927
definition A method that enables simultaneous detection of multiple biomarkers on a single tissue section using immunohistochemistry techniques.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
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publicId 9090863
value In situ hybridization
valueDescription in situ Hybridization
origin
beginDate 2022-03-25
endDate
deletedIndicator No
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dateCreated 2022-03-25
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dateModified 2022-03-25
ValueMeaning
publicId 2939763
version 1
longName in situ Hybridization
shortName 2939763
definition Use of a DNA or RNA probe to detect the presence of complementary sequences in chromosomes, cells, or tissues
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
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endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy CAMPBELB
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modifiedBy SBR
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Concepts
longName In Situ Hybridization
conceptCode C17562
definition Use of a DNA or RNA probe to detect the presence of complementary sequences in chromosomes, cells, or tissues.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
publicId 9090864
value IHC
valueDescription Immunohistochemistry Staining Method
origin
beginDate 2022-03-25
endDate
deletedIndicator No
createdBy COLBERTM
dateCreated 2022-03-25
modifiedBy ONEDATA
dateModified 2022-03-25
ValueMeaning
publicId 3031358
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longName Immunohistochemistry Staining Method
shortName 3031358
definition Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
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endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy ALAIS
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modifiedBy SOKKERL
dateModified 2023-12-01
Concepts
longName Immunohistochemistry Staining Method
conceptCode C23020
definition Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
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languageName ENGLISH
name IHC
type VM Alt Name
context COG
id 1B531F1F-001E-2672-E050-BB89AD4323C2
createdBy Mary J Cooper
dateCreated 2015-07-20
modifiedBy ONEDATA
dateModified 2015-07-20
languageName ENGLISH
name IHC (nuclear staining)
type HCMI Name
context OCG
id 65D54767-6D66-42FE-E053-F662850A58CF
createdBy Mary J Cooper
dateCreated 2018-02-22
modifiedBy COOPERM
dateModified 2018-02-22
languageName ENGLISH
name IHC
type VM Alt Name
context Theradex
id 0B733F82-F074-6623-E063-731AD00A64A2
createdBy Lamia Sokker
dateCreated 2023-12-01
modifiedBy SOKKERL
dateModified 2023-12-01
publicId 9189500
value Wright-Giemsa
valueDescription
origin
beginDate 2025-01-02
endDate
deletedIndicator No
createdBy COLBERTM
dateCreated 2025-01-02
modifiedBy COLBERTM
dateModified 2025-01-02
ValueMeaning
publicId 4908692
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longName Wright-Giemsa Staining Method
shortName 4908692
definition Geimsa is a polychromatic stain that permits the differentiation of cells present in hematopoietic tissues and for the demonstration of certain microorganisms. It is used for the detection of helicobacter pylori. The H. pylori and nuclei stain dark blue and cytoplasm stain pink with this stain (From BioGenex).
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2015-07-20
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy COOPERM
dateCreated 2015-07-20
modifiedBy SBR
dateModified 2018-01-19
Concepts
longName Wright-Giemsa Staining Method
conceptCode C23041
definition A microscopy staining method that combines the Wright and Giemsa staining protocols and utilizes Romanowsky stain variants containing eosin Y and thiazine dyes to enhance morphological detail in peripheral blood and bone marrow smears.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
Designations
languageName ENGLISH
name Wright-Giemsa
type VM Alt Name
context COG
id 1B531F1F-0006-2672-E050-BB89AD4323C2
createdBy Mary J Cooper
dateCreated 2015-07-20
modifiedBy ONEDATA
dateModified 2015-07-20
ConceptualDomain
publicId 2435018
version 1
longName Clinical or Research Activity
shortName C16203
definition Any specific activity undertaken during the course of a clinical study or research protocol.
context NCIP
origin NCI Thesaurus
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2005-12-06
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy CURTIST
dateCreated 2005-12-06
modifiedBy SBR
dateModified 2006-12-20
RepresentationTerm
publicId 2961453
version 1
longName Stain Type
shortName C841:C25284
definition A dye or other coloring material that is used in microscopy to make structures visible.:Type; a subdivision of a particular kind of thing.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2009-11-18
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy REEVESD
dateCreated 2009-11-18
modifiedBy ONEDATA
dateModified 2009-11-18
Concepts
longName Stain
conceptCode C841
definition A dye or other coloring material that is used in microscopy to make structures visible.
evsSource NCI_CONCEPT_CODE
primaryIndicator No
displayOrder 1
longName Type
conceptCode C25284
definition Something distinguishable as an identifiable class based on common qualities.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
ClassificationSchemes
publicId 5506116
version 1
longName Pathology
context MCL
workflowStatus RELEASED
registrationStatus Application
ClassificationSchemeItems
publicId 8115406
version 1
longName Pathology Imaging H&E Slide
context MCL
workflowStatus RELEASED
registrationStatus Application
publicId 10429357
version 1
longName GDC (Genomic Data Commons)
context CRDC
workflowStatus DRAFT NEW
registrationStatus Application
ClassificationSchemeItems
publicId 14506028
version 1
longName Candidate New GDC CDEs
context CRDC
workflowStatus DRAFT NEW
registrationStatus Application
publicId 13574489
version 1
longName CCDI (Childhood Cancer Data Initiative)
context Pediatric Cancer
workflowStatus RELEASED
registrationStatus Application
ClassificationSchemeItems
publicId 13594093
version 1
longName Sample
context Pediatric Cancer
workflowStatus RELEASED
registrationStatus Application
publicId 14470394
version 1
longName Pathology File
context Pediatric Cancer
workflowStatus RELEASED
registrationStatus Application
AlternateNames
name stain_type
type MCL Alt Name
context MCL
name staining_method
type CCDI Alt Name
context Pediatric Cancer
name pathology_file
type CCDI Table
context Pediatric Cancer
name stain_type
type GDC Alt Name
context GDC
ReferenceDocuments
documentName Stain type
documentText Stain type
documentType Preferred Question Text
url
context MCL
documentName MCL-Template Name
documentText PathologySlideScanDictionary_v0.1 - H&E
documentType Data Collection Template
url https://mcl.nci.nih.gov/resources/standards/mcl-cdes
context MCL
apiResponse
type S