| DataElement |
| publicId |
7789196 |
| version |
2 |
| longName |
Assay Type |
| shortName |
7789185v2.00:7789187v2.00 |
| definition |
The type of assay method or technology utilized to determine the amount of a particular constituent in a sample or the biological properties or activity of the sample. |
| context |
HTAN |
| origin |
HTAN:Human Tumor Atlas Network |
| workflowStatus |
DRAFT MOD |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
2/25/22 jk apprvd by SME, released for SRRS imaging data set. 2/3/22 jk upd WFS/RS, all PVs in VD. 10/27/21 jk added SRRS Biospecimen CSI. 9/28/21 jk HTAN Level 2 imaging data element, created for SRRS imaging data set. Incomplete term for IMC PV. |
| administrativeNotes |
8/5/26 Upd CTDC alt name from assay_subtype to assay_type per SN 6653/P.Breads. mr;
7/28/26 Added Olink PEA PV and Olink alt VM name for CTDC/CIDC/Patrick Breads per SN CADSR0006619. mr;
6/4/26 Corrected PV to mIF from MIF. note: H and E added back because it is both a stain and an assay. Resides in both 16964049 Specimen Staining Method Type and 7789196 Assay Type. mr;
6/4/26 Deleted GC staining_method alt name, alt def, CSI. Moved to 16964049 Specimen Staining Method Type per Amanda Bell in teams. mr;
4/22/26 Added PVs from CTDC model: H and E; IHC; scRNA-Seq; TCR-Seq and added corresponding CIDC alt names. mr;
4/8/26 added 9 PVs for CIDC/CTDC harmonization, CIDC lower case values added as alt VMs. 4 addl PVs pending new terms, 2 PVs under discussion as to applicability (they do not appear to be assay types). jk;
4/7/26 update Draft Mod CDE LN to reflect change in DEC and VD LN for concept change from C178865 (Assay Technology type) to C189101 (Assay Type) to better reflect PVs and intent of data value. jk
3/22/26 CDE versioned to incorporate revised Code Map OC DEC. jk;
3/9/26 Versioned VD to 2.0 to delete Staining Method PVs IHC C23020 and H&E C23011, which were moved to CDE 16964049 Specimen Staining Method Type and delete PV SABER C157991, which is a therapeutic procedure and not an assay or a stain. For GC. mr;
2/18/26 Deleted 2 HTAN CSIs (HTAN Biospecimen CDEs | Tier 2 Assay-specific and SRRS-Standardized Repository of Reference Specimens | SRRS Biospecimen) that were added in error on 1/23/26. mr;
1/23/26 Versioned CDE and DEC to 2.0 to update semantics in order to support both imaging and biospecimen nodes that have been using the same VD but different CDEs, and to support broader reuse based on CTDC/CIDC assay template input and minimize creation of node-specific CDEs that reuse the same VD/picklist. mr
9/24/24 added CyCIF, MERFISH, ExSeq PVs to support CDS/HTAN submission. jk;
2/6/24 Added CDS Alt name, def and CSI. BF; |
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2026-01-23 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-08-05 |
| DataElementConcept |
| publicId |
7789185 |
| version |
2 |
| longName |
Assay Type |
| shortName |
3167487v1.00:17137238v1.00 |
| definition |
A qualitative or quantitative analysis performed to determine the amount of a particular constituent in a sample or the biological or pharmacological properties or activity of a drug or substance.:The type of assay that was utilized. |
| context |
HTAN |
| origin |
HTAN:Human Tumor Atlas Network |
| workflowStatus |
DRAFT MOD |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
2/25/22 jk apprvd by SME, released for SRRS imaging data set. 9/28/21 jk HTAN Level 2 imaging data element, created for SRRS imaging data set. |
| administrativeNotes |
4/7/26 update Draft Mod DEC property concept from C178865 (Assay Technology type) to C189101 (Assay Type) to better reflect PVs and intent of data value. jk
1/27/26 Removed duplicate in LN. mr;
1/23/26 Versioned to 2.0 to update semantics in order to support both imaging and biospecimen nodes that have been using the same VD but different CDEs, and to support broader reuse based on CTDC/CIDC assay template input and minimize creation of node-specific CDEs that reuse the same VD/picklist. mr |
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2026-01-23 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-07 |
| ObjectClass |
| publicId |
3167487 |
| version |
1 |
| longName |
Assay |
| shortName |
C60819 |
| definition |
The determination of the amount of a particular constituent of a mixture or of the biological or pharmacological potency of a drug. |
| context |
NCIP |
| origin |
NCI Thesaurus |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2010-12-15 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
COOPERM |
| dateCreated |
2010-12-15 |
| modifiedBy |
ONEDATA |
| dateModified |
2010-12-15 |
| Concepts |
| longName |
Assay |
| conceptCode |
C60819 |
| definition |
A qualitative or quantitative analysis performed to determine the amount of a particular constituent in a sample or the biological or pharmacological properties or activity of a drug or substance. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
| Property |
| publicId |
17137238 |
| version |
1 |
| longName |
Assay Type |
| shortName |
C189101 |
| definition |
The type of assay that was utilized. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2026-04-07 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-07 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-07 |
| Concepts |
| longName |
Assay Type |
| conceptCode |
C189101 |
| definition |
The type of assay that was utilized. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
| ConceptualDomain |
| publicId |
2233241 |
| version |
1 |
| longName |
Medical Imaging |
| shortName |
MEDICAL IMAGING |
| definition |
Events, people, materials and activities uniquely defined by medical imaging. |
| context |
CIP |
| origin |
DICOM:Digital Imaging and Communications in Medicine |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2005-06-12 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
REEVESD |
| dateCreated |
2005-06-12 |
| modifiedBy |
SBREXT |
| dateModified |
2006-09-13 |
|
|
| ValueDomain |
| publicId |
7789187 |
| version |
2 |
| longName |
Assay Type |
| shortName |
7789187v2.00 |
| definition |
The type of a technology on which an assay is based._Something distinguishable as an identifiable class based on common qualities._The type of assay that was utilized. |
| context |
HTAN |
| type |
Enumerated |
| dataType |
CHARACTER |
| minLength |
|
| maxLength |
25 |
| minValue |
|
| maxValue |
|
| decimalPlace |
|
| origin |
HTAN:Human Tumor Atlas Network |
| workflowStatus |
DRAFT MOD |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
2/25/22 jk apprvd by SME, released for SRRS imaging data set. 9/28/21 jk HTAN Level 2 imaging data element, created for SRRS imaging data set. |
| administrativeNotes |
7/28/26 Added Olink PEA PV and Olink alt VM name for CTDC/Patrick Breads per SN CADSR0006619. mr;
6/4/26 Corrected PV to mIF from MIF. note: H and E added back because it is both a stain and an assay. Resides in both 16964049 Specimen Staining Method Type and 7789196 Assay Type. mr;
4/22/26 Added PVs from CTDC model: H and E; IHC; scRNA-Seq; TCR-Seq and added corresponding CIDC alt names. mr;
4/8/26 added 9 PVs for CIDC/CTDC harmonization, CIDC lower case values added as alt VMs. 4 addl PVs pending new terms, 2 PVs under discussion as to applicability (they do not appear to be assay types). jk;
4/7/26 update Draft Mod VD qualifier from C178865 (Assay Technology type) to C189101 (Assay Type) to better reflect PVs and intent of data value. jk
3/9/26 Versioned to 2.0 to delete Staining Method PVs IHC C23020 and H&E C23011, which were moved to CDE 16964049 Specimen Staining Method Type and delete PV SABER C157991, which is a therapeutic procedure and not an assay or a stain. mr;
9/25/24 Added PVs for CyCIF, MERFISH, ExSeq to support CDS/HTAN submission. jk |
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2026-03-09 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-07-28 |
| PermissibleValues |
| publicId |
9244214 |
| value |
GeoMX-DSP |
| valueDescription |
GeoMx Digital Spatial Profiler |
| origin |
|
| beginDate |
2021-09-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2026-03-09 |
| modifiedBy |
ONEDATA |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
7789193 |
| version |
1 |
| longName |
GeoMx Digital Spatial Profiler |
| shortName |
7789193 |
| definition |
A method to stain for RNA or protein from tissue sections that combines spatial and molecular profiling technologies by generating a whole tissue image at single cell resolution along with digital profiling data. A tissue section is reacted with up to 4 fluorescent morphology markers and tens to thousands of RNA or protein detection reagents barcoded with unique photocleavable oligonucleotides. The oligonucleotide markers are then imaged from regions of interest to be identified and quantitated. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2021-09-28 |
| modifiedBy |
ONEDATA |
| dateModified |
2021-09-28 |
| Concepts |
| longName |
GeoMx Digital Spatial Profiler |
| conceptCode |
C181933 |
| definition |
A method to stain for RNA or protein from tissue sections that combines spatial and molecular profiling technologies by generating a whole tissue image at single cell resolution along with digital profiling data. A tissue section is reacted with up to 4 fluorescent morphology markers and tens to thousands of RNA or protein detection reagents barcoded with unique photocleavable oligonucleotides. The oligonucleotide markers are then imaged from regions of interest to be identified and quantitated. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244215 |
| value |
CODEX |
| valueDescription |
CO-Detection by indEXing |
| origin |
|
| beginDate |
2021-09-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2026-03-09 |
| modifiedBy |
ONEDATA |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
7789194 |
| version |
1 |
| longName |
CO-Detection by indEXing |
| shortName |
7789194 |
| definition |
A highly multiplexed cytometric imaging approach used to create multiplexed datasets for a single tissue staining reaction. CODEX iteratively visualizes antibody binding events using DNA barcodes, fluorescent dNTP analogs, and an in situ polymerization-based indexing procedure. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2021-09-28 |
| modifiedBy |
ONEDATA |
| dateModified |
2021-09-28 |
| Concepts |
| longName |
CO-Detection by indEXing |
| conceptCode |
C181931 |
| definition |
A highly multiplexed cytometric imaging approach used to create multiplexed datasets for a single tissue staining reaction. CODEX iteratively visualizes antibody binding events using DNA barcodes, fluorescent dNTP analogs, and an in situ polymerization-based indexing procedure. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244216 |
| value |
MIBI |
| valueDescription |
Multiplexed Ion Beam Imaging |
| origin |
|
| beginDate |
2021-09-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2026-03-09 |
| modifiedBy |
ONEDATA |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
7789195 |
| version |
1 |
| longName |
Multiplexed Ion Beam Imaging |
| shortName |
7789195 |
| definition |
A method for multiplexed immunohistochemistry that uses secondary ion mass spectrometry to image antibodies tagged with isotopically pure elemental metal reporters. Multiplexed ion beam imaging (MIBI) is capable of analyzing up to 100 targets simultaneously over a five-log dynamic range. This technique enables comprehensive phenotypic profiling and spatial analysis of the tissue microenvironment. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2021-09-28 |
| modifiedBy |
ONEDATA |
| dateModified |
2021-09-28 |
| Concepts |
| longName |
Multiplexed Ion Beam Imaging |
| conceptCode |
C181930 |
| definition |
A method for multiplexed immunohistochemistry that uses secondary ion mass spectrometry to image antibodies tagged with isotopically pure elemental metal reporters. Multiplexed ion beam imaging (MIBI) is capable of analyzing up to 100 targets simultaneously over a five-log dynamic range. This technique enables comprehensive phenotypic profiling and spatial analysis of the tissue microenvironment. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244217 |
| value |
IMC |
| valueDescription |
Imaging Mass Cytometry |
| origin |
|
| beginDate |
2021-09-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2026-03-09 |
| modifiedBy |
ONEDATA |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
7789409 |
| version |
1 |
| longName |
Imaging Mass Cytometry |
| shortName |
7789409 |
| definition |
A proprietary method that combines laser ablation of tissue specimens with secondary ion mass spectrometry to image antibodies tagged with isotopically pure elemental metal reporters. This technique allows for in situ characterization of the specimen while preserving its tissue architecture and cellular morphology. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2021-09-28 |
| modifiedBy |
ONEDATA |
| dateModified |
2021-09-28 |
| Concepts |
| longName |
Imaging Mass Cytometry |
| conceptCode |
C182027 |
| definition |
A proprietary method that combines laser ablation of tissue specimens with secondary ion mass spectrometry to image antibodies tagged with isotopically pure elemental metal reporters. This technique allows for in situ characterization of the specimen while preserving its tissue architecture and cellular morphology. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244220 |
| value |
mIF |
| valueDescription |
Multiplexed Immunofluorescence |
| origin |
|
| beginDate |
2021-09-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2026-03-09 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-06-04 |
| ValueMeaning |
| publicId |
7789190 |
| version |
1 |
| longName |
Multiplexed Immunofluorescence |
| shortName |
7789190 |
| definition |
A method that enables simultaneous detection of multiple biomarkers on a single tissue section using immunofluorescence techniques. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2021-09-28 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| Concepts |
| longName |
Multiplexed Immunofluorescence |
| conceptCode |
C181928 |
| definition |
A method that enables simultaneous detection of multiple biomarkers on a single tissue section using immunofluorescence techniques. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
MxIF |
| type |
CIDC Alt Name |
| context |
CRDC |
| id |
501124D9-ABE5-542C-E063-731AD00AA660 |
| createdBy |
Maureen Ryan |
| dateCreated |
2026-04-22 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
|
|
|
|
| publicId |
9244221 |
| value |
mIHC |
| valueDescription |
Multiplexed Immunohistochemistry |
| origin |
|
| beginDate |
2021-09-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2026-03-09 |
| modifiedBy |
ONEDATA |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
7789191 |
| version |
1 |
| longName |
Multiplexed Immunohistochemistry |
| shortName |
7789191 |
| definition |
A method that enables simultaneous detection of multiple biomarkers on a single tissue section using immunohistochemistry techniques. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2021-09-28 |
| modifiedBy |
ONEDATA |
| dateModified |
2021-09-28 |
| Concepts |
| longName |
Multiplexed Immunohistochemistry |
| conceptCode |
C181927 |
| definition |
A method that enables simultaneous detection of multiple biomarkers on a single tissue section using immunohistochemistry techniques. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244223 |
| value |
t-CyCIF |
| valueDescription |
Tissue-Based Cyclic Immunofluorescence |
| origin |
|
| beginDate |
2021-09-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2026-03-09 |
| modifiedBy |
ONEDATA |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
7789192 |
| version |
1 |
| longName |
Tissue-Based Cyclic Immunofluorescence |
| shortName |
7789192 |
| definition |
A method for immunofluorescence imaging of formalin-fixed, paraffin-embedded (FFPE) specimens mounted on glass slides that generates images using an iterative, cycling process in which conventional fluorescence images capturing up to 60 targets are repeatedly collected from the same sample and then assembled into a high-dimensional representation of the spacial relationships between the multiplex targets. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-09-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2021-09-28 |
| modifiedBy |
ONEDATA |
| dateModified |
2021-09-28 |
| Concepts |
| longName |
Tissue-Based Cyclic Immunofluorescence |
| conceptCode |
C181929 |
| definition |
A method for immunofluorescence imaging of formalin-fixed, paraffin-embedded (FFPE) specimens mounted on glass slides that generates images using an iterative, cycling process in which conventional fluorescence images capturing up to 60 targets are repeatedly collected from the same sample and then assembled into a high-dimensional representation of the spacial relationships between the multiplex targets. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244224 |
| value |
ExSeq |
| valueDescription |
|
| origin |
|
| beginDate |
2024-09-25 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-03-09 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
15156945 |
| version |
1 |
| longName |
Expansion Sequencing |
| shortName |
15156945v1.00 |
| definition |
A next generation sequencing technique that can analyze the transcriptome in fixed samples that combines fluorescent in situ sequencing (FISSEQ) with expansion microscopy, which physically expands biological specimens. A specimen is fixed to a slide, the RNA are bound using an anchor and the sample is then embedded in a swellable polymer, which isotropically enlarges the structural elements in the sample without damaging their spatial relationships. Then the specimen is subjected to FISSEQ, where the RNAs are converted into a random or targeted cDNA amplicon library, which is subjected to sequencing using fluorescent probes, and the sequences are determined using high resolution confocal microscopy. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2024-09-25 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2024-09-25 |
| modifiedBy |
JKNABLE |
| dateModified |
2024-09-25 |
| Concepts |
| longName |
Expansion Sequencing |
| conceptCode |
C210698 |
| definition |
A next generation sequencing technique that can analyze the transcriptome in fixed samples that combines fluorescent in situ sequencing (FISSEQ) with expansion microscopy, which physically expands biological specimens. A specimen is fixed to a slide, the RNA are bound using an anchor and the sample is then embedded in a swellable polymer, which isotropically enlarges the structural elements in the sample without damaging their spatial relationships. Then the specimen is subjected to FISSEQ, where the RNAs are converted into a random or targeted cDNA amplicon library, which is subjected to sequencing using fluorescent probes, and the sequences are determined using high resolution confocal microscopy. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244225 |
| value |
MERFISH |
| valueDescription |
|
| origin |
|
| beginDate |
2024-09-25 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-03-09 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
15156944 |
| version |
1 |
| longName |
Multiplexed Error-Robust Fluorescence In Situ Hybridization |
| shortName |
15156944v1.00 |
| definition |
A system that leverages the single-molecule fluorescent in situ hybridization (FISH)-based method to perform spatially-resolved single-cell transcriptome profiling for multiple genes of interest. The system leverages combinatorial labeling where each gene in the panel is assigned a unique binary barcode. Then the sample is stained with barcode-specific probes that are subjected sequential rounds of imaging using fluorescently-labeled probes where each round corresponds to one bit in the binary code; thus, multiple rounds of imaging are read to assemble each barcode. Finally, the system can analyze readout errors and either assign the nearest correct barcode or reject background signals. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2024-09-25 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2024-09-25 |
| modifiedBy |
JKNABLE |
| dateModified |
2024-09-25 |
| Concepts |
| longName |
Multiplexed Error-Robust Fluorescence In Situ Hybridization |
| conceptCode |
C210697 |
| definition |
A system that leverages the single-molecule fluorescent in situ hybridization (FISH)-based method to perform spatially-resolved single-cell transcriptome profiling for multiple genes of interest. The system leverages combinatorial labeling where each gene in the panel is assigned a unique binary barcode. Then the sample is stained with barcode-specific probes that are subjected sequential rounds of imaging using fluorescently-labeled probes where each round corresponds to one bit in the binary code; thus, multiple rounds of imaging are read to assemble each barcode. Finally, the system can analyze readout errors and either assign the nearest correct barcode or reject background signals. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244226 |
| value |
CyCIF |
| valueDescription |
|
| origin |
|
| beginDate |
2024-09-25 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-03-09 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
15156943 |
| version |
1 |
| longName |
Cyclic Immunofluorescence |
| shortName |
15156943v1.00 |
| definition |
A method for highly multiplexed immunofluorescent imaging of cells in various formats, such as tissue sections and multi-well tissue culture plates, using fluorescent microscopy. Images are generated using an iterative, cycling process in which images of expressed fluorescently-tagged proteins, fluorescent dyes, or fluorescently-tagged primary or secondary antibodies can be serially collected from the same sample and then those images can be assembled into a high-dimensional representation of the spatial relationships between the targets of interest. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2024-09-25 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2024-09-25 |
| modifiedBy |
JKNABLE |
| dateModified |
2024-09-25 |
| Concepts |
| longName |
Cyclic Immunofluorescence |
| conceptCode |
C210700 |
| definition |
A method for highly multiplexed immunofluorescent imaging of cells in various formats, such as tissue sections and multi-well tissue culture plates, using fluorescent microscopy. Images are generated using an iterative, cycling process in which images of expressed fluorescently-tagged proteins, fluorescent dyes, or fluorescently-tagged primary or secondary antibodies can be serially collected from the same sample and then those images can be assembled into a high-dimensional representation of the spatial relationships between the targets of interest. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9244227 |
| value |
Not Applicable |
| valueDescription |
|
| origin |
|
| beginDate |
2024-09-19 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-03-09 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-03-09 |
| ValueMeaning |
| publicId |
7590024 |
| version |
1 |
| longName |
Not Applicable |
| shortName |
7590024 |
| definition |
Determination of a value is not relevant in the current context. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2021-03-04 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
3/4/25 Added alt VM names per RFC 26 CR 1. sl;
7/8/22 added alt name of NA for CCTG cjl; |
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
MORENOC |
| dateCreated |
2021-03-04 |
| modifiedBy |
COLBERTM |
| dateModified |
2025-09-22 |
| Concepts |
| longName |
Not Applicable |
| conceptCode |
C48660 |
| definition |
Determination of a value is not relevant in the current context. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
NA |
| type |
VM Alt Name |
| context |
CCTG |
| id |
E34CD13D-81FB-2BBA-E053-731AD00AB0FB |
| createdBy |
Cassandra Lohnes |
| dateCreated |
2022-07-08 |
| modifiedBy |
CLOHNES |
| dateModified |
2022-07-08 |
|
| languageName |
ENGLISH |
| name |
N/A, not prescribed by protocol this reporting period |
| type |
VM Alt Name |
| context |
COG |
| id |
EA35C2DA-C729-3F38-E053-731AD00A9CCF |
| createdBy |
Angela Kummerow |
| dateCreated |
2022-10-04 |
| modifiedBy |
KUMMEROA |
| dateModified |
2022-10-04 |
|
| languageName |
ENGLISH |
| name |
NA |
| type |
C3D Name |
| context |
CCR |
| id |
F5D00E09-1D00-6E85-E053-731AD00A77EA |
| createdBy |
Gwen Deen |
| dateCreated |
2023-02-28 |
| modifiedBy |
GDEEN |
| dateModified |
2023-02-28 |
|
| languageName |
ENGLISH |
| name |
NA for this agent |
| type |
VM Alt Name |
| context |
COG |
| id |
F8AE92A0-F4C9-1809-E053-731AD00A6B10 |
| createdBy |
Angela Kummerow |
| dateCreated |
2023-04-06 |
| modifiedBy |
KUMMEROA |
| dateModified |
2023-04-06 |
|
| languageName |
ENGLISH |
| name |
NA |
| type |
VM Alt Name |
| context |
COG |
| id |
00DA8EBF-21BA-2258-E063-731AD00A0F8E |
| createdBy |
Angela Kummerow |
| dateCreated |
2023-07-19 |
| modifiedBy |
KUMMEROA |
| dateModified |
2023-07-19 |
|
| languageName |
ENGLISH |
| name |
Not Applicable |
| type |
VM Alt Name |
| context |
COG |
| id |
0141F8E8-EFE4-18FA-E063-731AD00A676C |
| createdBy |
Angela Kummerow |
| dateCreated |
2023-07-24 |
| modifiedBy |
KUMMEROA |
| dateModified |
2023-07-24 |
|
| languageName |
ENGLISH |
| name |
N/A |
| type |
VM Alt Name |
| context |
COG |
| id |
0B4B588E-4730-61D5-E063-731AD00AB570 |
| createdBy |
Angela Kummerow |
| dateCreated |
2023-11-29 |
| modifiedBy |
KUMMEROA |
| dateModified |
2023-11-29 |
|
| languageName |
ENGLISH |
| name |
NA=Not applicable |
| type |
Context Short Name |
| context |
NCIP |
| id |
19AE2677-6E0C-28C0-E063-731AD00A5982 |
| createdBy |
Angela Kummerow |
| dateCreated |
2024-05-30 |
| modifiedBy |
KUMMEROA |
| dateModified |
2024-05-30 |
|
| languageName |
ENGLISH |
| name |
-1 |
| type |
TCIA Alt Name |
| context |
CIP |
| id |
1F44C544-C2A6-5787-E063-731AD00A90D9 |
| createdBy |
Bobbie Fincham |
| dateCreated |
2024-08-09 |
| modifiedBy |
FINCHAMB |
| dateModified |
2024-08-09 |
|
| languageName |
ENGLISH |
| name |
NA |
| type |
TCIA Alt Name |
| context |
CIP |
| id |
1F9540D2-CF45-727C-E063-731AD00AECD1 |
| createdBy |
Bobbie Fincham |
| dateCreated |
2024-08-13 |
| modifiedBy |
FINCHAMB |
| dateModified |
2024-08-13 |
|
| languageName |
ENGLISH |
| name |
No linguistic content; Not applicable |
| type |
FHIR US CORE Name |
| context |
CDMH |
| id |
2436D81A-27E7-0510-E063-731AD00A8228 |
| createdBy |
Xiaoyun Zhang |
| dateCreated |
2024-10-11 |
| modifiedBy |
ZHWENDY |
| dateModified |
2024-10-11 |
|
| languageName |
ENGLISH |
| name |
Not Applicable |
| type |
CDA Alt Name |
| context |
CRDC |
| id |
2F8EF754-2B80-2DA9-E063-731AD00AAF1C |
| createdBy |
Sarah Lauer |
| dateCreated |
2025-03-04 |
| modifiedBy |
SLAUER |
| dateModified |
2025-03-04 |
|
| languageName |
ENGLISH |
| name |
N/A |
| type |
CDA Alt Name |
| context |
CRDC |
| id |
2F8EF754-2B81-2DA9-E063-731AD00AAF1C |
| createdBy |
Sarah Lauer |
| dateCreated |
2025-03-04 |
| modifiedBy |
SLAUER |
| dateModified |
2025-03-04 |
|
| languageName |
ENGLISH |
| name |
Not Applicable |
| type |
GC Alt Name |
| context |
CRDC |
| id |
2F8EF754-2B82-2DA9-E063-731AD00AAF1C |
| createdBy |
Sarah Lauer |
| dateCreated |
2025-03-04 |
| modifiedBy |
SLAUER |
| dateModified |
2025-03-04 |
|
| languageName |
ENGLISH |
| name |
Not Applicable |
| type |
ICDC Alt Name |
| context |
CRDC |
| id |
2F8EF754-2B83-2DA9-E063-731AD00AAF1C |
| createdBy |
Sarah Lauer |
| dateCreated |
2025-03-04 |
| modifiedBy |
SLAUER |
| dateModified |
2025-03-04 |
|
| languageName |
ENGLISH |
| name |
Not Applicable |
| type |
HTAN Alt Name |
| context |
HTAN |
| id |
2F8EF754-2B84-2DA9-E063-731AD00AAF1C |
| createdBy |
Sarah Lauer |
| dateCreated |
2025-03-04 |
| modifiedBy |
SLAUER |
| dateModified |
2025-03-04 |
|
| languageName |
ENGLISH |
| name |
NA |
| type |
CTDC Alt Name |
| context |
CRDC |
| id |
3F646051-E809-15A0-E063-731AD00A1B37 |
| createdBy |
Maureen Ryan |
| dateCreated |
2025-09-22 |
| modifiedBy |
COLBERTM |
| dateModified |
2025-09-22 |
|
|
|
|
| publicId |
9245280 |
| value |
ELISA |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-08 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-08 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-08 |
| ValueMeaning |
| publicId |
3173905 |
| version |
1 |
| longName |
ELISA |
| shortName |
3173905 |
| definition |
A highly sensitive technique for detecting and measuring antigens or antibodies in a solution; the solution is run over a surface to which immobilized antibodies specific to the substance have been attatched, and if the substance is present, it will bind to the antibody layer, and its presence is verified and visualized with an application of antibodies that have been tagged in some way. (BioTech Life Science Dictionary) |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2010-12-21 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
MAESKEB |
| dateCreated |
2010-12-21 |
| modifiedBy |
SBR |
| dateModified |
2018-01-19 |
| Concepts |
| longName |
ELISA |
| conceptCode |
C16553 |
| definition |
A highly sensitive technique for detecting and measuring antigens or antibodies in a solution; the solution is run over a surface to which immobilized antibodies specific to the substance have been attached, and if the substance is present, it will bind to the antibody layer, and its presence is verified and visualized with an application of antibodies that have been tagged in some way. (BioTech Life Science Dictionary) |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9245281 |
| value |
CyTOF |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-08 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-08 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-08 |
| ValueMeaning |
| publicId |
11009258 |
| version |
1 |
| longName |
Mass Cytometry |
| shortName |
11009258v1.00 |
| definition |
A flow cytometry technique that utilizes mass spectrometry to detect antibodies labeled with heavy metal ion tags that are bound to antigens of interest on single cells. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2022-08-08 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KUMMEROA |
| dateCreated |
2022-08-08 |
| modifiedBy |
KUMMEROA |
| dateModified |
2022-08-08 |
| Concepts |
| longName |
Mass Cytometry |
| conceptCode |
C187898 |
| definition |
A flow cytometry technique that utilizes mass spectrometry to detect antibodies labeled with heavy metal ion tags that are bound to antigens of interest on single cells. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9245282 |
| value |
ctdDNA |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-08 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-08 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-08 |
| ValueMeaning |
| publicId |
4061103 |
| version |
1 |
| longName |
Circulating Tumor-Derived DNA |
| shortName |
4061103v1.00 |
| definition |
Neoplasm-derived DNA found in blood plasma and other bodily fluids that is not associated with cells. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2014-01-09 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2014-01-09 |
| modifiedBy |
GDEEN |
| dateModified |
2023-08-01 |
| Concepts |
| longName |
Circulating Tumor-Derived DNA |
| conceptCode |
C113243 |
| definition |
Neoplasm-derived DNA found in blood plasma and other bodily fluids that is not associated with cells. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
ctDNA |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
07AB85B7-CA76-79FC-E050-BB89AD434450 |
| createdBy |
Denise Warzel |
| dateCreated |
2014-11-12 |
| modifiedBy |
ONEDATA |
| dateModified |
2014-11-12 |
|
| languageName |
ENGLISH |
| name |
ctdDNA |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
07AB85B7-CA78-79FC-E050-BB89AD434450 |
| createdBy |
Denise Warzel |
| dateCreated |
2014-11-12 |
| modifiedBy |
ONEDATA |
| dateModified |
2014-11-12 |
|
| languageName |
ENGLISH |
| name |
DPBTD |
| type |
Biomarker Synonym |
| context |
SPOREs |
| id |
559EDF1E-4863-494F-E053-F662850A20E2 |
| createdBy |
Maureen Ryan |
| dateCreated |
2017-07-31 |
| modifiedBy |
ONEDATA |
| dateModified |
2017-07-31 |
|
| languageName |
ENGLISH |
| name |
Cell-Free Circulating Tumor DNA |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27D-F18F-720F-E053-731AD00A94C0 |
| createdBy |
Load Job Administrator |
| dateCreated |
2023-02-16 |
| modifiedBy |
ONEDATA_WA |
| dateModified |
2023-02-16 |
|
| languageName |
ENGLISH |
| name |
Circulating Tumor DNA |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27D-F190-720F-E053-731AD00A94C0 |
| createdBy |
Load Job Administrator |
| dateCreated |
2023-02-16 |
| modifiedBy |
ONEDATA_WA |
| dateModified |
2023-02-16 |
|
| languageName |
ENGLISH |
| name |
Circulating tumor-derived DNA |
| type |
Manually-curated |
| context |
NCIP |
| id |
01E3EBAF-F855-3C9A-E063-731AD00AE9B5 |
| createdBy |
Gwen Deen |
| dateCreated |
2023-08-01 |
| modifiedBy |
GDEEN |
| dateModified |
2023-08-01 |
|
|
|
|
| publicId |
9245283 |
| value |
ATAC-Seq |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-08 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-08 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-08 |
| ValueMeaning |
| publicId |
6273353 |
| version |
1 |
| longName |
ATAC-seq |
| shortName |
6273353v1.00 |
| definition |
A molecular genetic technique that isolates and sequences chromosomal regions that are rich in open chromatin. First, nuclei are harvested from a cellular sample. Then a hyperactive Tn5 transposase is added to the nuclei where it excises non-nucleosomal DNA strands and ligates co-administered high-throughput sequencing adapters (tagmentation). The tagged DNA fragments are isolated, amplified by PCR and sequenced. The number of reads for specific region of DNA correlate with increased chromatin accessibility and this method can identify regions of transcription factor and nucleosome binding. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2018-05-11 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KNABLEJ |
| dateCreated |
2018-05-11 |
| modifiedBy |
COLBERTM |
| dateModified |
2024-03-19 |
| Concepts |
| longName |
ATAC-Seq |
| conceptCode |
C156056 |
| definition |
A molecular genetic technique that isolates and sequences chromosomal regions that are rich in open chromatin. First, nuclei are harvested from a cellular sample. Then a hyperactive Tn5 transposase is added to the nuclei where it excises non-nucleosomal DNA strands and ligates co-administered high-throughput sequencing adapters (tagmentation). The tagged DNA fragments are isolated, amplified by PCR and sequenced. The number of reads for specific region of DNA correlate with increased chromatin accessibility and this method can identify regions of transcription factor and nucleosome binding. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9245286 |
| value |
NULISA |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-08 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-08 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-08 |
| ValueMeaning |
| publicId |
17139458 |
| version |
1 |
| longName |
Nucleic Acid-Linked Immuno-Sandwich Assay |
| shortName |
17139458v1.00 |
| definition |
An ultra-sensitive, multiplexed proteomic sandwich immunosorbent assay platform that uses DNA-barcoded antibodies, biotin-mediated immunocomplex capture, PCR-based amplification and next-generation sequencing (NGS) to measure the expression of hundreds of low-abundance proteins with attomolar-level sensitivity. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2026-04-08 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-08 |
| modifiedBy |
JKNABLE |
| dateModified |
2026-04-08 |
| Concepts |
| longName |
Nucleic Acid-Linked Immuno-Sandwich Assay |
| conceptCode |
C226687 |
| definition |
An ultra-sensitive, multiplexed proteomic sandwich immunosorbent assay platform that uses DNA-barcoded antibodies, biotin-mediated immunocomplex capture, PCR-based amplification and next-generation sequencing (NGS) to measure the expression of hundreds of low-abundance proteins with attomolar-level sensitivity. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9245287 |
| value |
RNA-Seq |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-08 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2026-04-08 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| ValueMeaning |
| publicId |
5076611 |
| version |
1 |
| longName |
Whole Transcriptome Sequencing |
| shortName |
5076611 |
| definition |
A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an individual. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2015-12-07 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2015-12-07 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| Concepts |
| longName |
Whole Transcriptome Sequencing |
| conceptCode |
C124261 |
| definition |
A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an individual. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
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Total RNA-Seq |
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NCIP |
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28B031BF-7DB9-8EF0-E050-BB89AD436449 |
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2016-01-06 |
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ONEDATA |
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2016-01-06 |
|
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ENGLISH |
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Biomarker Synonym |
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NCIP |
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28B031BF-7DBB-8EF0-E050-BB89AD436449 |
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2016-01-06 |
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2016-01-06 |
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Biomarker Synonym |
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NCIP |
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28B031BF-7DBC-8EF0-E050-BB89AD436449 |
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Denise Warzel |
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2016-01-06 |
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2016-01-06 |
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Total RNA Sequencing |
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Biomarker Synonym |
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NCIP |
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28B031BF-7DBD-8EF0-E050-BB89AD436449 |
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Denise Warzel |
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2016-01-06 |
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ONEDATA |
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2016-01-06 |
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RNA Sequencing |
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Biomarker Synonym |
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NCIP |
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F4D4B27E-05B4-720F-E053-731AD00A94C0 |
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Biomarker Synonym |
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NCIP |
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F4D4B27E-05B5-720F-E053-731AD00A94C0 |
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Load Job Administrator |
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2023-02-16 |
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ONEDATA_WA |
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2023-02-16 |
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RNA-seq (transcriptome sequencing) |
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Biomarker Synonym |
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NCIP |
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F4D4B27E-05B6-720F-E053-731AD00A94C0 |
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Load Job Administrator |
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2023-02-16 |
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ONEDATA_WA |
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2023-02-16 |
|
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ENGLISH |
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Biomarker Synonym |
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NCIP |
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Load Job Administrator |
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ONEDATA_WA |
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2023-02-16 |
|
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ENGLISH |
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WHOLE TRANSCRIPTOME SEQUENCING |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27E-05B8-720F-E053-731AD00A94C0 |
| createdBy |
Load Job Administrator |
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2023-02-16 |
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ONEDATA_WA |
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2023-02-16 |
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WTSS |
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NCIP |
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F4D4B27E-05B9-720F-E053-731AD00A94C0 |
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Load Job Administrator |
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2023-02-16 |
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ONEDATA_WA |
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2023-02-16 |
|
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ENGLISH |
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Whole Transcriptome Shotgun Sequencing |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27E-05BA-720F-E053-731AD00A94C0 |
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Load Job Administrator |
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2023-02-16 |
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ONEDATA_WA |
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2023-02-16 |
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Biomarker Synonym |
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NCIP |
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FAAA0F24-31EC-1C16-E053-731AD00AEAC0 |
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Load Job Administrator |
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2023-05-01 |
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ONEDATA_WA |
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2023-05-01 |
|
| languageName |
ENGLISH |
| name |
RNA-seq (transcriptome sequencing) |
| type |
Biomarker Synonym |
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NCIP |
| id |
05A2C088-89D1-20CA-E063-731AD00A73DC |
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Load Job Administrator |
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2023-09-18 |
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ONEDATA_WA |
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2023-09-18 |
|
| languageName |
ENGLISH |
| name |
RNA-Seq |
| type |
CRDC Alt Name |
| context |
CRDC |
| id |
3D37213B-12C9-046C-E063-731AD00AC47D |
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Maureen Ryan |
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2025-08-25 |
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COLBERTM |
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2025-08-25 |
|
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| name |
Whole transcriptome sequencing |
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VM Alt Name |
| context |
COG |
| id |
4D3DDAE1-C389-3595-E063-731AD00A0317 |
| createdBy |
Angela Kummerow |
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2026-03-17 |
| modifiedBy |
KUMMEROA |
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2026-03-17 |
|
| languageName |
ENGLISH |
| name |
Sequencing, Whole Transcriptome |
| type |
VM Alt Name |
| context |
COG |
| id |
500DD9D7-CDBC-6D38-E063-731AD00AD17E |
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Sarah Lauer |
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2026-04-22 |
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SLAUER |
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2026-04-22 |
|
| languageName |
ENGLISH |
| name |
rnaseq |
| type |
CIDC Alt Name |
| context |
CRDC |
| id |
501127E7-7660-54AA-E063-731AD00A5EC2 |
| createdBy |
Maureen Ryan |
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2026-04-22 |
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COLBERTM |
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2026-04-22 |
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9245288 |
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3589477 |
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Exome Sequencing |
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3589477 |
| definition |
A procedure that can determine the DNA sequence for all of the exons in an individual. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
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2012-09-14 |
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REEVESD |
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2012-09-14 |
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SLAUER |
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2026-04-22 |
| Concepts |
| longName |
Whole Exome Sequencing |
| conceptCode |
C101295 |
| definition |
A procedure that can determine the DNA sequence for all of the exons in an individual. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
WES |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
1E2629DD-4E85-838D-E050-BB89AD430258 |
| createdBy |
Maureen Ryan |
| dateCreated |
2015-08-25 |
| modifiedBy |
ONEDATA |
| dateModified |
2015-08-25 |
|
| languageName |
ENGLISH |
| name |
Whole Exome Sequencing |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
1E2629DD-4E87-838D-E050-BB89AD430258 |
| createdBy |
Maureen Ryan |
| dateCreated |
2015-08-25 |
| modifiedBy |
ONEDATA |
| dateModified |
2015-08-25 |
|
| languageName |
ENGLISH |
| name |
Whole-Exome Sequencing |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
1E2629DD-4E88-838D-E050-BB89AD430258 |
| createdBy |
Maureen Ryan |
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2015-08-25 |
| modifiedBy |
ONEDATA |
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2015-08-25 |
|
| languageName |
ENGLISH |
| name |
Exome |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27D-F58F-720F-E053-731AD00A94C0 |
| createdBy |
Load Job Administrator |
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2023-02-16 |
| modifiedBy |
ONEDATA_WA |
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2023-02-16 |
|
| languageName |
ENGLISH |
| name |
Exome Sequencing |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27D-F590-720F-E053-731AD00A94C0 |
| createdBy |
Load Job Administrator |
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2023-02-16 |
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ONEDATA_WA |
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2023-02-16 |
|
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ENGLISH |
| name |
WXS |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27D-F591-720F-E053-731AD00A94C0 |
| createdBy |
Load Job Administrator |
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2023-02-16 |
| modifiedBy |
ONEDATA_WA |
| dateModified |
2023-02-16 |
|
| languageName |
ENGLISH |
| name |
WXS (whole exome sequencing) |
| type |
Biomarker Synonym |
| context |
NCIP |
| id |
F4D4B27D-F592-720F-E053-731AD00A94C0 |
| createdBy |
Load Job Administrator |
| dateCreated |
2023-02-16 |
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ONEDATA_WA |
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2023-02-16 |
|
| languageName |
ENGLISH |
| name |
Sequencing, Whole Exome |
| type |
VM Alt Name |
| context |
COG |
| id |
500DD9D7-CDBD-6D38-E063-731AD00AD17E |
| createdBy |
Sarah Lauer |
| dateCreated |
2026-04-22 |
| modifiedBy |
SLAUER |
| dateModified |
2026-04-22 |
|
|
|
|
| publicId |
9270278 |
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TCR-Seq |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-22 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2026-04-22 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| ValueMeaning |
| publicId |
17179176 |
| version |
1 |
| longName |
T Cell Receptor Repertoire Sequencing |
| shortName |
17179176v1.00 |
| definition |
A sequencing analysis used to identify alpha/beta or gamma/delta T-cell receptors (TCRs) in a biological sample or specimen. TCR repertoire sequencing allows for the identification of biomarkers of disease or of clinical response to treatment. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2026-04-22 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2026-04-22 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| Concepts |
| longName |
T Cell Receptor Repertoire Sequencing |
| conceptCode |
C189102 |
| definition |
A sequencing analysis used to identify alpha/beta or gamma/delta T-cell receptors (TCRs) in a biological sample or specimen. TCR repertoire sequencing allows for the identification of biomarkers of disease or of clinical response to treatment. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
tcr |
| type |
CIDC Alt Name |
| context |
CRDC |
| id |
5010FA79-307F-49C2-E063-731AD00A3DF0 |
| createdBy |
Maureen Ryan |
| dateCreated |
2026-04-22 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
|
|
|
|
| publicId |
9270279 |
| value |
scRNA-Seq |
| valueDescription |
|
| origin |
|
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2026-04-22 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
| dateCreated |
2026-04-22 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| ValueMeaning |
| publicId |
12373577 |
| version |
1 |
| longName |
Single Cell RNA Sequencing |
| shortName |
12373577v1.00 |
| definition |
A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an amplified nucleotide sample that was derived from a single cell. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2023-01-16 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
JKNABLE |
| dateCreated |
2023-01-16 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| Concepts |
| longName |
Single Cell RNA Sequencing |
| conceptCode |
C171152 |
| definition |
A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an amplified nucleotide sample that was derived from a single cell. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
scrnaseq |
| type |
CIDC Alt Name |
| context |
CRDC |
| id |
5010F7E8-9F42-490C-E063-731AD00AC7A5 |
| createdBy |
Maureen Ryan |
| dateCreated |
2026-04-22 |
| modifiedBy |
COLBERTM |
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2026-04-22 |
|
|
|
|
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9270280 |
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H and E |
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|
| origin |
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2026-04-22 |
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No |
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COLBERTM |
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2026-04-22 |
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COLBERTM |
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2026-04-22 |
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| publicId |
4588572 |
| version |
1 |
| longName |
Hematoxylin and Eosin Staining Method |
| shortName |
4588572 |
| definition |
Hematoxylin-and-eosin, or H&E, is a routine staining procedure of tissue sections. This staining method uses two separate dyes, one staining the nucleus and the other staining the cytoplasm and connective tissue. Hematoxylin is a dark purplish dye that stains the chromatin (nuclear material) within the nucleus. Eosin is an orangish-pink to red dye that stains the cytoplasmic material including connective tissue and collagen. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2014-11-12 |
| endDate |
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| changeDescription |
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| administrativeNotes |
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| unresolvedIssues |
|
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No |
| createdBy |
COOPERM |
| dateCreated |
2014-11-12 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
| Concepts |
| longName |
Hematoxylin and Eosin Staining Method |
| conceptCode |
C23011 |
| definition |
Hematoxylin-and-eosin, or H&E, is a routine staining procedure of tissue sections. This staining method uses two separate dyes, one staining the nucleus and the other staining the cytoplasm and connective tissue. Hematoxylin is a dark purplish dye that stains the chromatin (nuclear material) within the nucleus. Eosin is an orangish-pink to red dye that stains the cytoplasmic material including connective tissue and collagen. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
H&E |
| type |
VM Alt Name |
| context |
COG |
| id |
1B531F1F-001C-2672-E050-BB89AD4323C2 |
| createdBy |
Mary J Cooper |
| dateCreated |
2015-07-20 |
| modifiedBy |
ONEDATA |
| dateModified |
2015-07-20 |
|
| languageName |
ENGLISH |
| name |
hande |
| type |
CIDC Alt Name |
| context |
CRDC |
| id |
5010F583-CA80-48BE-E063-731AD00A5499 |
| createdBy |
Maureen Ryan |
| dateCreated |
2026-04-22 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-04-22 |
|
|
|
|
| publicId |
9270281 |
| value |
IHC |
| valueDescription |
|
| origin |
|
| beginDate |
2026-04-22 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
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2026-04-22 |
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COLBERTM |
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2026-04-22 |
| ValueMeaning |
| publicId |
2926796 |
| version |
1 |
| longName |
Immunohistochemistry Staining Method |
| shortName |
2926796 |
| definition |
Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2009-08-03 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
CURTIST |
| dateCreated |
2009-08-03 |
| modifiedBy |
SBR |
| dateModified |
2018-01-19 |
| Concepts |
| longName |
Immunohistochemistry Staining Method |
| conceptCode |
C23020 |
| definition |
Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| publicId |
9274248 |
| value |
Olink PEA |
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|
| origin |
|
| beginDate |
2026-07-28 |
| endDate |
|
| deletedIndicator |
No |
| createdBy |
COLBERTM |
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2026-07-28 |
| modifiedBy |
COLBERTM |
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2026-07-28 |
| ValueMeaning |
| publicId |
16626703 |
| version |
1 |
| longName |
Proximity Extension Assay |
| shortName |
16626703v1.00 |
| definition |
A type of multiplex immunoassay that utilizes pairs of oligonucleotide-labeled antibodies to detect and quantify proteins in a sample. In this assay, the antibodies bind to their target proteins, and when in close proximity, the oligonucleotides are extended and amplified through a polymerase reaction. The resulting DNA products are then quantified using real-time PCR, allowing for sensitive and specific measurement of protein levels in complex biological samples. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2025-10-28 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
| createdBy |
KUMMEROA |
| dateCreated |
2025-10-28 |
| modifiedBy |
COLBERTM |
| dateModified |
2026-07-28 |
| Concepts |
| longName |
Proximity Extension Assay |
| conceptCode |
C221636 |
| definition |
A type of multiplex immunoassay that utilizes pairs of oligonucleotide-labeled antibodies to detect and quantify proteins in a sample. In this assay, the antibodies bind to their target proteins, and when in close proximity, the oligonucleotides are extended and amplified through a polymerase reaction. The resulting DNA products are then quantified using real-time PCR, allowing for sensitive and specific measurement of protein levels in complex biological samples. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
| Designations |
| languageName |
ENGLISH |
| name |
Olink |
| type |
CIDC Alt Name |
| context |
CRDC |
| id |
57B1A037-7AD6-139D-E063-731AD00AE083 |
| createdBy |
Maureen Ryan |
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2026-07-28 |
| modifiedBy |
COLBERTM |
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2026-07-28 |
|
|
|
|
|
| ConceptualDomain |
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2233241 |
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1 |
| longName |
Medical Imaging |
| shortName |
MEDICAL IMAGING |
| definition |
Events, people, materials and activities uniquely defined by medical imaging. |
| context |
CIP |
| origin |
DICOM:Digital Imaging and Communications in Medicine |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2005-06-12 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
| deletedIndicator |
No |
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REEVESD |
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2005-06-12 |
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SBREXT |
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2006-09-13 |
|
| RepresentationTerm |
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17137239 |
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1 |
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Assay Type Type |
| shortName |
17137239v1.00 |
| definition |
The type of assay that was utilized._Something distinguishable as an identifiable class based on common qualities. |
| context |
NCIP |
| origin |
|
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| latestVersionIndicator |
Yes |
| beginDate |
2026-04-07 |
| endDate |
|
| changeDescription |
|
| administrativeNotes |
|
| unresolvedIssues |
|
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No |
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JKNABLE |
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2026-04-07 |
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JKNABLE |
| dateModified |
2026-04-07 |
| Concepts |
| longName |
Assay Type |
| conceptCode |
C189101 |
| definition |
The type of assay that was utilized. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
No |
| displayOrder |
1 |
|
| longName |
Type |
| conceptCode |
C25284 |
| definition |
Something distinguishable as an identifiable class based on common qualities. |
| evsSource |
NCI_CONCEPT_CODE |
| primaryIndicator |
Yes |
| displayOrder |
0 |
|
|
|
|
| ClassificationSchemes |
| publicId |
7639423 |
| version |
1 |
| longName |
SRRS-Standardized Repository of Reference Specimens |
| context |
HTAN |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| ClassificationSchemeItems |
| publicId |
7639428 |
| version |
1 |
| longName |
SRRS Imaging |
| context |
HTAN |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
|
|
|
| publicId |
7788578 |
| version |
1 |
| longName |
HTAN Imaging CDEs |
| context |
HTAN |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| ClassificationSchemeItems |
| publicId |
7788582 |
| version |
1 |
| longName |
Imaging Data Tier 2 |
| context |
HTAN |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
|
|
|
| publicId |
11518160 |
| version |
1 |
| longName |
CTDC (Clinical and Translational Data Commons) |
| context |
CRDC |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| ClassificationSchemeItems |
| publicId |
14413713 |
| version |
1 |
| longName |
Biospecimen |
| context |
CRDC |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
|
|
|
| publicId |
17012038 |
| version |
1 |
| longName |
IDC (Imaging Data Commons) |
| context |
CRDC |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
| ClassificationSchemeItems |
| publicId |
17012049 |
| version |
1 |
| longName |
Multiplex Imaging |
| context |
CRDC |
| workflowStatus |
RELEASED |
| registrationStatus |
Application |
|
|
|
|
| AlternateNames |
| name |
ImagingAssayType |
| type |
HTAN Alt Name |
| context |
HTAN |
|
| name |
imaging_assay_type |
| type |
GC Alt Name |
| context |
CRDC |
|
| name |
ASSAY_TYPE |
| type |
HTAN Alt Name |
| context |
HTAN |
|
| name |
imaging_assay_type |
| type |
IDC Alt Name |
| context |
CRDC |
|
| name |
assay_type |
| type |
CTDC Alt Name |
| context |
CRDC |
|
| name |
Assay |
| type |
CTDC Table |
| context |
CRDC |
|
|
| ReferenceDocuments |
| documentName |
PQT |
| documentText |
Assay Type |
| documentType |
Preferred Question Text |
| url |
|
| context |
HTAN |
|
|
|