DataElement
publicId 12373576
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shortName 11555652v1.00:12373575v3.00
definition The type of systematic investigation using controlled observations and measurements to test hypotheses or develop a plan of action based on the facts discovered.
context CRDC
origin CDS:Cancer Data Service
workflowStatus RELEASED
registrationStatus Standard
latestVersionIndicator Yes
beginDate 2023-01-16
endDate
changeDescription
administrativeNotes 9/8/25 added "Quantitative Immunofluorescence" and "Immunofluorescence" per GC SN CADSR0005354, approved by per RR/Heather. jk; 8/25/25 Versioned to 3.0 to modify PVs at request of CCDI/P.Dunn and GC/Amanda Bell, with approval of Heather Creasy and Robinette Renner. mr; 5/21/25 Added alt name, alt def, per June 2025 GDC DD. sl; 4/13/25 Released per CRDC DSS SC mtg 3/26/25 and RFC 62. mr; 1/15/25 Added PV LC-MS/MS, which was deleted from Molecular Exptl Strategy CDE 15194011. With agreement of CDS and CCDI (Amanda B and Pat D) we are retiring Molecular Exptl Strategy CDE 15194011 to streamline these CDEs. mr; 11/13/24 removed "size_of_data_being_uploaded" property alt name that was in Henry's CCDI model XLS. Not a semantic match to this CDE. jk; 10/24/24 per Henry/CodeMap task, add alt table, nameLS; 10/16/24 Upd CRDC alt def. mr; 10/7/24 Added CRDC std CSI, alt name, alt def. mr; 10/2/24 Versioned to 2.0 to delete PVs Bisulfite-Seq, WGA, WXS that are already present in child CDE Library Strategy 6273393. mr; 9/19/24 changed ALT Name type from GDC Name to GDC ALT Name. bf; 9/17/24 Per CRDC Model submission XLS, added Alt Name and CSI for CRDC Submission Model and GDC. bf; 7/24/24 per PD/CCDI and AB/CDS, changed alt name capturing property name to "experimental_strategy". jk; 5/28/24 Added Methylation Analysis as PV to support CDS, and added CDS alt name of Methylation. mr 2/20/24 AI released per SME/Amanda Bell approval. ls 5/16/23 changed origin to CDS. BF; 1/16/23 created for CRDC CDS template. jk
unresolvedIssues
deletedIndicator No
createdBy COLBERTM
dateCreated 2025-08-25
modifiedBy JKNABLE
dateModified 2025-09-08
DataElementConcept
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version 1
longName Research Activity Experimental Method
shortName 3693395v1.00:2224069v1.00
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context CRDC
origin CDS:Cancer Data Service
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2022-11-05
endDate
changeDescription
administrativeNotes 2/20/24 AI released per SME/Amanda Bell approval.ls5/17/23 changed origin to CDS. BF; 11/5/22 created for CDS data element. jk
unresolvedIssues
deletedIndicator No
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ObjectClass
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context NCIP
origin NCI Thesaurus
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registrationStatus Application
latestVersionIndicator Yes
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endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
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modifiedBy ONEDATA
dateModified 2013-03-06
Concepts
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conceptCode C15429
definition Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
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publicId 2224069
version 1
longName Experimental Method
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definition The use of controlled observations and measurements to test hypotheses.
context NCIP
origin NCI Thesaurus
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
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endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
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conceptCode C43622
definition The use of controlled observations and measurements to test hypotheses.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
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definition Any specific activity undertaken during the course of a clinical study or research protocol.
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registrationStatus Application
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administrativeNotes
unresolvedIssues
deletedIndicator No
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ValueDomain
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definition The use of controlled observations and measurements to test hypotheses._Something distinguishable as an identifiable class based on common qualities.
context CRDC
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dataType CHARACTER
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origin CDS:Cancer Data Service
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administrativeNotes 9/8/25 added "Quantitative Immunofluorescence" and "Immunofluorescence" per GC SN CADSR0005354 per RR/Heather approval. jk; 8/25/25 Versioned to 3.0 to modify PVs at request of CCDI/P.Dunn and GC/Amanda Bell, with approval of Heather Creasy and Robinette Renner. PV changes were as follows: Removed “Methylation Array” PV, retained “Methylation Analysis” PV; Replaced “Archer Fusion” PV with more generic “Multigene Expression Assay”. Associated the PV with C210244 (Multiplex Gene Expression Panel Assay); Changed 'DNA-Seq' PV to ‘DNA Sequencing’. ‘DNA-Seq’ will be added as an Alt Name. No change in concept is needed; Changed 'RNA-Seq' PV to ‘RNA Sequencing’. ‘RNA-Seq’ will be added as an Alt Name. No change in concept is needed; 'Pathological' was changed to “Pathology” and associated with C18189 (Pathology); 'Radiological' was changed to “Radiology”. No change in concept is needed. mr; 4/13/25 Released per CRDC DSS SC mtg 3/26/25. mr; 1/15/25 Added PV LC-MS/MS, which was deleted from Molecular Exptl Strategy CDE 15194011. With agreement of CDS and CCDI (Amanda B and Pat D) we are retiring Molecular Exptl Strategy CDE 15194011 to streamline these CDEs. mr; 12/18/24 Removed scRNA-Seq PV. It is in the child/related CDE 6273393 Library Sequencing Technique Type since it is a child of RNA-Seq. mr; 10/2/24 Versioned to 2.0 to remove WGA, WXS, and Bisulfite-Seq PVs, which are already in child CDE 6273393 Library Strategy. mr; 5/28/24 Added Methylation Analysis as PV to support CDS, and added CDS alt name of Methylation. mr 5/15/24 added DNA-SEQ as PV to support CDS, and alt name of DNA-seq. jk; 2/20/24 AI released per SME/Amanda Bell approval.ls5/17/23 changed origin to CDS. BF; 2/1/23 added values per 1/31 email from Amanda; pending description for remaining value of Archer_Fusion. jk; 1/16/23 created for CRDC CDS template. jk
unresolvedIssues
deletedIndicator No
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ValueMeaning
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definition A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an individual.
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endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
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dateModified 2026-04-22
Concepts
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conceptCode C124261
definition A procedure that can determine the nucleotide sequence for all of the RNA transcripts in an individual.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
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deletedIndicator No
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context NCIP
origin
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registrationStatus Application
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changeDescription
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unresolvedIssues
deletedIndicator No
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Concepts
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primaryIndicator Yes
displayOrder 0
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deletedIndicator No
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context NCIP
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endDate
changeDescription
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unresolvedIssues
deletedIndicator No
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unresolvedIssues
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definition Something distinguishable as an identifiable class based on common qualities.
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longName Study
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workflowStatus RELEASED
registrationStatus Application
publicId 10429357
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longName GDC (Genomic Data Commons)
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workflowStatus DRAFT NEW
registrationStatus Application
ClassificationSchemeItems
publicId 14506028
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longName Candidate New GDC CDEs
context CRDC
workflowStatus DRAFT NEW
registrationStatus Application
publicId 10466051
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longName All CRDC Standard CDEs
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registrationStatus Application
ClassificationSchemeItems
publicId 10466056
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longName Molecular
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workflowStatus RELEASED
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publicId 13574489
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longName CCDI (Childhood Cancer Data Initiative)
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registrationStatus Application
ClassificationSchemeItems
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longName Study
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workflowStatus RELEASED
registrationStatus Application
publicId 13596246
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longName Study Identification
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publicId 15103644
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longName CRDC Submission Model
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registrationStatus Application
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longName File
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AlternateNames
name Experimental Strategy
type CRDC Alt Name
context CRDC
name study
type CCDI Table
context Pediatric Cancer
name experimental_strategy
type CRDC Model Alt Name
context CRDC
name experimental_strategies
type GDC Alt Name
context CRDC
name experimental_strategy
type GC Alt Name
context CRDC
name experimental_strategy
type CCDI Alt Name
context Pediatric Cancer
name experimental_strategy
type GDC Alt Name
context GDC
ReferenceDocuments
documentName CDS
documentText If multiple strategies and data subtypes exist, please separate with semicolons.
documentType Coding Instructions
url
context CRDC
documentName PQT
documentText Experimental Strategy
documentType Preferred Question Text
url
context CRDC
documentName CDS
documentText WXS, RNA-Seq, Pathological, Radiological, scRNA-seq
documentType EXAMPLE
url
context CRDC
apiResponse
type S