DataElement
publicId 11325685
version 2
longName Subject Tumor Grade
shortName 11323463v2.00:11323466v2.00
definition A text term to express the degree of abnormality of cancer cells as a measure of differentiation and aggressiveness.
context CRDC
origin CRDC:Cancer Research Data Commons
workflowStatus RELEASED
registrationStatus Standard
latestVersionIndicator Yes
beginDate 2022-09-27
endDate
changeDescription
administrativeNotes 3/25/26 Added CIDC Appendix A alt name, table, def. CSI already present. mr; 5/22/25 Classified in GDC Candidate CSI, added alt name, alt def, per June 2025 GDC DD. sl; 3/11/25 Released per RFC 26 CR1 node agreement in preparation for 3/26/25 DSS SC mtg. mr; 3/4/25 Added alt VM names per RFC 26 CR 1. sl; 3/4/25 Versioned to 2.0 to upd PV list to match CRDC DSS RFC 26CR updates. Deleted PVs for G1-G4, High, Intermediate, Low Grades and replaced with hybrid PVs 'G1 Low Grade' etc. to accommodate CDA. mr; 1/2/25 Removed CCDI alt name tumor_grade_source, which does not belong on this CDE. This is CCDI tumor_grade. tumor_grade_source will need a new/different CDE. mr; 12/18/24 add PDC Alt Name per RFC actual data review. jk; 9/25/24 removed "X" from alt name per jk. bf; 8/29/24: Fixing PV's, shifting to ALT VM's of existing PV's for Advanced MRI. bf;. 8/9/24 added TCIA Alt name, Advanced MRI classification and PV's. bf; 3/17/24 added TCIA Adv BA Alt Name. jk; 12/31/23 Added CDS Imaging CSI. jk; 8/7/23 Added Alt Name for CDE with source of “DSS” in the CTDC data model. BF; 1/23/23 Added alt name, CDS CSI per CDS metadata template. mr; 10/16/22 Released per email from Wendy Ver Hoef 10/14/22 6:08pm. mr; 10/2/22 Edited concepts in DEC and VD. mr; 9/27/22 Created for CRDC RFC26.mr
unresolvedIssues
deletedIndicator No
createdBy COLBERTM
dateCreated 2025-03-03
modifiedBy COLBERTM
dateModified 2026-03-25
DataElementConcept
publicId 11323463
version 2
longName Subject Tumor Grade
shortName 2523466v1.00:2427327v1.00
definition A matter or an individual that is observed, analyzed, examined, investigated, experimented upon, or/and treated in the course of a particular study.:The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems.
context CRDC
origin CRDC:Cancer Research Data Commons
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2022-09-27
endDate
changeDescription
administrativeNotes 3/13/26 Updated WFS to Released. sl; 3/4/25 Upd OC to Subject from Diagnosis per Code Map and to accommodate ICDC, who captures Tumor Grade in their specimen/sample module. mr; 10/16/22 Released per CRDC DSS. mr; 10/4/22 Edited long name. mr; 10/2 & 10/3/22 Edited concepts. mr; 9/27/22 Created for CRDC RFC 26. mr;
unresolvedIssues
deletedIndicator No
createdBy COLBERTM
dateCreated 2025-03-03
modifiedBy SLAUER
dateModified 2026-03-13
ObjectClass
publicId 2523466
version 1
longName Study Subject
shortName C41189
definition A matter or person that is analyzed, examined, investigated, experimented upon, or treated in the course of particular study.
context NCIP
origin NCI Thesaurus
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2006-09-27
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy UMLLOADER_DRUGSCREEN
dateCreated 2006-09-27
modifiedBy SBREXT
dateModified 2007-11-07
Concepts
longName Study Subject
conceptCode C41189
definition A matter or an individual that is observed, analyzed, examined, investigated, experimented upon, or/and treated in the course of a particular study.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
Property
publicId 2427327
version 1
longName Grade
shortName C18000
definition Describes how closely a cancer resembles normal tissue of its same type, and the cancer's probable rate of growth
context NCIP
origin NCI Thesaurus
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2005-11-09
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy ALAIS
dateCreated 2005-11-09
modifiedBy ONEDATA
dateModified 2005-11-09
Concepts
longName Histologic Grade
conceptCode C18000
definition The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
ConceptualDomain
publicId 2008537
version 1
longName Diagnosis
shortName DX
definition the process of identifying a disease by the signs and symptoms (NCI Glossary).
context CTEP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2002-12-17
endDate
changeDescription
administrativeNotes
unresolvedIssues
deletedIndicator No
createdBy MSUPLEY
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modifiedBy SBR
dateModified 2003-10-29
ValueDomain
publicId 11323466
version 2
longName Tumor Grade
shortName 11323466v2.00
definition The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems._A position on a scale of intensity or amount or quality.
context CRDC
type Enumerated
dataType CHARACTER
minLength
maxLength 50
minValue
maxValue
decimalPlace
origin CRDC:Cancer Research Data Commons
workflowStatus RELEASED
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changeDescription
administrativeNotes 3/13/26 Updated WFS to Released. sl; 3/4/25 Added alt VM names per RFC 26 CR 1. sl; 3/3/25 Versioned to 2.0 to upd PV list to match CRDC DSS RFC 26 updates. Deleted PVs for G1-G4, High, Intermediate, Low Grades and replaced with hybrid PVs 'G1 Low Grade' etc. to accommodate CDA. mr; 8/29/24 Removing TCIA Advanced MRI PV's and shifting to alt names of existing PV's, low, medium high. bf;8/9/24 added PV's and ALT VM's for TCIA Advanced MRI. bf; 7/30/23 added Unknown as PV per Smita's request to support CDA. jk; 3/27/23 added Not Reported PV to support CDS. jk; 10/16/22 Released per CRDC DSS. mr; 10/2 & 10/3/22 Edited concepts. mr; 9/27/22 Created for CRDC RFC26. mr
unresolvedIssues
deletedIndicator No
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dateModified 2026-03-13
PermissibleValues
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value GB Borderline
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origin
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endDate
deletedIndicator No
createdBy COLBERTM
dateCreated 2025-03-03
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dateModified 2025-03-03
ValueMeaning
publicId 6050322
version 1
longName Grade B
shortName 6050322
definition A morphologic qualifier indicating that a neoplasm is of borderline malignancy.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2018-01-09
endDate
changeDescription
administrativeNotes 3/4/25 Added alt VM names per RFC 26 CR 1. sl
unresolvedIssues
deletedIndicator No
createdBy LUY
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modifiedBy SLAUER
dateModified 2025-03-04
Concepts
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conceptCode C113729
definition A morphologic qualifier indicating that a neoplasm is of borderline malignancy.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
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context CRDC
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dateCreated 2025-03-04
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languageName ENGLISH
name GB
type CCDI Alt Name
context Pediatric Cancer
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longName Grade X
shortName 10987209v1.00
definition A morphologic qualifier indicating that the grade of a neoplasm cannot be assessed.
context NCIP
origin
workflowStatus RELEASED
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beginDate 2022-08-05
endDate
changeDescription
administrativeNotes 3/4/25 Added alt VM names per RFC 26 CR 1. sl; 3/4/25 Added CMB alt VM name. mr
unresolvedIssues
deletedIndicator No
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definition A morphologic qualifier indicating that the grade of a neoplasm cannot be assessed.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
Designations
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name Grade or differentiation not determined, not stated or not applicable
type VM Alt Name
context PMI
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context CRDC
id 2F87B3B6-FE1E-4A08-E063-731AD00A0AE1
createdBy Maureen Ryan
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context HTAN
id 2F8ABED1-33E8-7BDC-E063-731AD00AABCA
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type CTDC Alt Name
context CRDC
id 3D848A61-1916-4FFE-E063-731AD00AF91C
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ValueMeaning
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shortName 7590024
definition Determination of a value is not relevant in the current context.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
beginDate 2021-03-04
endDate
changeDescription
administrativeNotes 3/4/25 Added alt VM names per RFC 26 CR 1. sl; 7/8/22 added alt name of NA for CCTG cjl;
unresolvedIssues
deletedIndicator No
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dateModified 2025-09-22
Concepts
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definition Determination of a value is not relevant in the current context.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
Designations
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context CCTG
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context COG
id EA35C2DA-C729-3F38-E053-731AD00A9CCF
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dateCreated 2022-10-04
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deletedIndicator No
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ValueMeaning
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definition Not provided or available.
context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
latestVersionIndicator Yes
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endDate
changeDescription
administrativeNotes 3/4/25 Added alt VM names per RFC 26 CR 1. sl; 10/10/23 changed Long Name from "Not Stated" to match NCIt Preferred name and current caDSR concept Long Name of "Not Reported" per Brenda.Janice . LS
unresolvedIssues
deletedIndicator No
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modifiedBy SLAUER
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Concepts
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definition Not provided or available.
evsSource NCI_CONCEPT_CODE
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Designations
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context COG
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valueDescription
origin
beginDate 2023-07-30
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deletedIndicator No
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context NCIP
origin
workflowStatus RELEASED
registrationStatus Application
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beginDate 2017-02-27
endDate
changeDescription
administrativeNotes 3/4/25 Added alt VM names per RFC 26 CR 1. sl
unresolvedIssues
deletedIndicator No
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modifiedBy COLBERTM
dateModified 2025-04-17
Concepts
longName Unknown
conceptCode C17998
definition Not known, observed, recorded; or reported as unknown by the data contributor.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
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Designations
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id 2F8A829D-DB09-70D6-E063-731AD00AA9A5
createdBy Sarah Lauer
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languageName ENGLISH
name G4
type HTAN Alt Name
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createdBy Bobbie Fincham
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languageName ENGLISH
name Grade 4
type TCIA Alt Name
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id 3751654C-1433-7A4A-E063-731AD00A7AD4
createdBy Bobbie Fincham
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languageName ENGLISH
name Undifferentiated grade
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id 3D847FBF-906C-4E8D-E063-731AD00A7CA9
createdBy Maureen Ryan
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longName Diagnosis
shortName DX
definition the process of identifying a disease by the signs and symptoms (NCI Glossary).
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beginDate 2002-12-17
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changeDescription
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unresolvedIssues
deletedIndicator No
createdBy MSUPLEY
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RepresentationTerm
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longName Histologic Grade Grade
shortName C18000:C48309
definition The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems.:A position on a scale of intensity or amount or quality.
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administrativeNotes
unresolvedIssues
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Concepts
longName Histologic Grade
conceptCode C18000
definition The degree of abnormality of cancer cells, a measure of differentiation, the extent to which cancer cells are similar in appearance and function to healthy cells of the same tissue type. The degree of differentiation often relates to the clinical behavior of the particular tumor. Based on the microscopic findings, tumor grade is commonly described by one of four degrees of severity. Histopathologic grade of a tumor may be used to plan treatment and estimate the future course, outcome, and overall prognosis of disease. Certain types of cancers, such as soft tissue sarcoma, primary brain tumors, lymphomas, and breast have special grading systems.
evsSource NCI_CONCEPT_CODE
primaryIndicator No
displayOrder 1
longName Grade
conceptCode C48309
definition A position on a scale of intensity or amount or quality.
evsSource NCI_CONCEPT_CODE
primaryIndicator Yes
displayOrder 0
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longName TCIA (The Cancer Imaging Archive)
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longName Harmonized Clinical Data Submissions
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registrationStatus Application
publicId 14678978
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longName Advanced-MRI-Breast-Lesions
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longName MU-Glioma-Post-Clinical
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longName UCSD-PTGBM-Clinical
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longName HistologyHSI-BRCA-Recurrence
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longName GC (General Commons)
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longName Diagnosis
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registrationStatus Application
publicId 14470388
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longName Imaging
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longName Candidate New GDC CDEs
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longName Diagnosis
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longName CTDC (Clinical and Translational Data Commons)
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workflowStatus RELEASED
registrationStatus Application
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longName Cancer Moonshot Biobank
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workflowStatus RELEASED
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name GRADE
type TCIA Alt Name
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name tumor_grade
type PDC Alt Name
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name diagnosis
type CTDC Table
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name Grade
type TCIA Alt Name
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name tumor_grade
type CTDC Alt Name
context CRDC
name Tumor Grade
type CRDC Alt Name
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name tumor_grade
type GC Alt Name
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name tumor_grade
type CCDI Alt Name
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name Tumor Grade
type CMB Alt Name
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name Grade of Primary Brain Tumor
type TCIA Alt Name
context CIP
name tumor_grade
type GDC Alt Name
context GDC
name Tumor_histologic_grade
type TCIA Alt Name
context CIP
name tumor_grade
type CIDC Alt Name
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name disease
type CIDC Table
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ReferenceDocuments
documentName PQT
documentText Tumor Grade
documentType Preferred Question Text
url
context CRDC
documentName TCIA Instructions
documentText The order of the lesions for each patient is all tumors first (corresponding to DICOM SEG tags tumor1, tumor2 and so on) followed by all benign lesions (corresponding to the tags bening1, benign2 and so on).
documentType Instructions
url
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